Pcdh17 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in synaptic membrane adhesion. Predicted to act upstream of or within several processes, including negative regulation of synaptic transmission; presynaptic active zone assembly; and regulation of synaptic vesicle clustering. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Orthologous to human PCDH17 (protocadherin 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcdh17 |
| Official Name | protocadherin 17 [Source:RGD Symbol;Acc:1304753] |
| Ensembl ID | ENSRNOG00000008970 |
| Bio databases IDs | |
| Aliases | protocadherin 17 |
| Synonyms | C030033F14RIK, Gm78, LOC144997, PCDH68, PCH68, protocadherin 17 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcdh17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- Cadherin-like
- Cadherin repeat-like domain
- protein binding
- extracellular cadherin structural domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- schizophrenia
- angioimmunoblastic T-cell lymphoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- phosphorylation in
- expression in
- accumulation in
- adhesion
- accumulation
- synaptic transmission
- area
- clustering
- assembly
- synaptic transmission in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- protein-cell contact site
- perisynaptic region
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- dendritic spines
- synapse
- presynaptic terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcdh17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic vesicle clustering
- negative regulation of synaptic transmission
- cell adhesion
- homophilic cell adhesion
- adult behavior
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding