Efnb1 Gene Summary [Rat]
Predicted to enable ephrin receptor binding activity. Involved in presynapse assembly. Located in synapse. Is active in glutamatergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome and dysostosis. Orthologous to human EFNB1 (ephrin B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efnb1 |
| Official Name | ephrin B1 [Source:RGD Symbol;Acc:2540] |
| Ensembl ID | ENSRNOG00000006877 |
| Bio databases IDs | |
| Aliases | ephrin B1 |
| Synonyms | Cek5-L, CFND, CFNS, EFB1, EFL-3, Elk-L, Ephrin-B1, Epl2, EPLG2, LERK-2, Stra1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Efnb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Ephrin
- Cupredoxin superfamily
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- ephrin receptor binding
- protein binding
- cytosolic tail domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Efnb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- colon cancer
- obesity
- craniofrontonasal dysplasia
- hereditary disorder
- bone resorption disorder
- omphalocele
- early missed abortion
- rheumatoid arthritis
- neonatal late-onset sepsis
role in cell
- expression in
- differentiation
- survival
- proliferation
- apoptosis
- phosphorylation in
- activation in
- production in
- size
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- cell borders
- cellular membrane
- Nucleus
- apical membrane
- presynaptic membrane
- lateral plasma membrane
- neurites
- synapse
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Efnb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural crest cell migration
- T cell costimulation
- embryonic pattern specification
- ephrin receptor signaling pathway
- T cell proliferation
- cell-cell signaling
- regulation of autophagic vacuole assembly
- axon guidance
- cell adhesion
- positive regulation of T cell proliferation
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane raft
- synapse
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding