Sh3bp4 Gene Summary [Rat]
Predicted to enable GDP-dissociation inhibitor activity; identical protein binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of GTPase activity; negative regulation of TOR signaling; and protein localization to lysosome. Predicted to be located in clathrin-coated pit; clathrin-coated vesicle; and nucleus. Predicted to be active in cytoplasm. Orthologous to human SH3BP4 (SH3 domain binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3bp4 |
| Official Name | SH3-domain binding protein 4 [Source:RGD Symbol;Acc:620219] |
| Ensembl ID | ENSRNOG00000019316 |
| Bio databases IDs | |
| Aliases | SH3-domain binding protein 4 |
| Synonyms | AW227605, BOG25, EHB10, LOC100361116, SH3-domain binding protein 4, TTP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh3bp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GDP-dissociation inhibitor
- NPF motif
- enzyme binding
- protein binding
- identical protein binding
- ZU5 domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Sh3bp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- androgenic alopecia
- cholelithiasis
- orofacial cleft
- chronic kidney disease
- gallstone
- major depression
- Huntington disease
- infection by Hepatitis C virus genotype 2
- infection by HIV
regulates
- GTPase
- dynamin
- FGFR2
role in cell
- proliferation
- degradation in
- migration
- growth
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh3bp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid stimulus
- positive regulation of autophagy
- negative regulation of GTPase activity
- negative regulation of cell growth
- negative regulation of cell proliferation
- regulation of catalytic activity
- endocytosis
- negative regulation of TOR signaling cascade
- amino acid import
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- coated pit
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- GDP-dissociation inhibitor activity
- protein binding
- small GTPase binding