Tead4 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic organ development; hippo signaling; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including embryo implantation; positive regulation of stem cell population maintenance; and trophectodermal cell fate commitment. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-DNA complex and transcription regulator complex. Orthologous to human TEAD4 (TEA domain transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tead4 |
| Official Name | TEA domain transcription factor 4 [Source:RGD Symbol;Acc:1585671] |
| Ensembl ID | ENSRNOG00000005608 |
| Bio databases IDs | |
| Aliases | TEA domain transcription factor 4 |
| Synonyms | EFTR-2, ETFR-2, FR-19, hRTEF-1B, RTEF1, TCF13L1, Tcf13r1, TEA domain family member 4, TEA domain transcription factor 4, TEF-3, Tefr, TEFR-1, Tefr1a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tead4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- YAP binding domain
- protein binding
- TEA/ATTS domain
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Pathways
Biological processes and signaling networks where the Tead4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon cancer
- organismal death
- colon epithelial cancer
- bladder cancer
- colorectal adenoma
- colorectal adenoma formation
- colon carcinoma
- metastasis
- gastric cancer
role in cell
- expression in
- proliferation
- activation in
- formation
- formation in
- phosphorylation in
- quantity
- migration
- binding in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tead4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- trophectodermal cell fate commitment
- skeletal system development
- transcription, DNA-dependent
- hippo signaling cascade
- embryonic organ development
- cell fate specification
- positive regulation of transcription from RNA polymerase II promoter
- embryo implantation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity