Lipf Gene Summary [Rat]
Enables malate dehydrogenase activity and triacylglycerol lipase activity. Acts upstream of or within malate metabolic process. Located in mitochondrion. Orthologous to human LIPF (lipase F, gastric type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lipf |
| Official Name | lipase F, gastric type [Source:RGD Symbol;Acc:708441] |
| Ensembl ID | ENSRNOG00000019448 |
| Bio databases IDs | |
| Aliases | lipase F, gastric type |
| Synonyms | gastric lipase, GL, HGL, HLAL, lipase F, gastric type, RNLIP, RNLP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lipf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- malate dehydrogenase
- alpha/beta hydrolases
- Partial alpha/beta-hydrolase lipase region
- lipase
- enzyme
- protein binding
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the Lipf gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatitis
- hepatic steatosis
- overweight disorder
- obesity
- non-insulin-dependent diabetes mellitus
- gastric adenocarcinoma
- gastric epithelial cancer
- binge eating disorder
- heart disease
- weight regain
regulates
- triolein
- malic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lipf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- malate metabolic process
- lipid catabolic process
- triglyceride metabolic process
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- mitochondrion
- extracellular region
Molecular Function
What the gene product does at the molecular level
- malate dehydrogenase activity
- triglyceride lipase activity
- lipid binding