Itga2

Enables collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cellular component organization; and positive regulation of metabolic process. Located in several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. Is active in presynapse. Biomarker of placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itga2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Itga2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Itga2 gene, providing context for its role in the cell.