Slc20a2 Gene Summary [Rat]
Enables sodium:phosphate symporter activity. Predicted to be involved in phosphate ion transmembrane transport and positive regulation of bone mineralization. Located in apical plasma membrane and brush border membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human SLC20A2 (solute carrier family 20 member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc20a2 |
| Official Name | solute carrier family 20 member 2 [Source:RGD Symbol;Acc:3699] |
| Ensembl ID | ENSRNOG00000019490 |
| Bio databases IDs | |
| Aliases | solute carrier family 20 member 2 |
| Synonyms | Ab1-188, GLVR-2, IBGC1, IBGC2, IBGC3, LOC100507493, LOC100508150, MLVAR, MolPit2, PIT-2, RAM-1, solute carrier family 20 member 2, solute carrier family 20, member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc20a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- viral receptor
- sodium:phosphate symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic basal ganglia calcification type 1
- hereditary disorder
- acute myeloid leukemia
- familial idiopathic basal ganglia calcification
- gout
- tonsillitis
role in cell
- mineralization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc20a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- ion transport
- sodium ion transmembrane transport
- positive regulation of bone mineralization
- phosphate ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- extracellular vesicular exosome
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inorganic phosphate transmembrane transporter activity
- sodium:phosphate symporter activity
- signaling receptor activity
- viral receptor activity