Depdc5 Gene Summary [Rat]
Predicted to enable small GTPase binding activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be located in cytosol; lysosome; and perinuclear region of cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex and GATOR1 complex. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and familial focal epilepsy with variable foci 1. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Depdc5 |
| Official Name | DEP domain containing 5, GATOR1 subcomplex subunit [Source:RGD Symbol;Acc:1311535] |
| Ensembl ID | ENSRNOG00000018144 |
| Bio databases IDs | |
| Aliases | DEP domain containing 5, GATOR1 subcomplex subunit |
| Synonyms | DEE111, DEP.5, DEP domain containing 5, DEP domain containing 5, GATOR1 subcomplex subunit, FFEVF, FFEVF1, FPEVF, KIAA0645 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Depdc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vacuolar membrane-associated protein Iml1
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- binding protein
- DEPDC5 protein C-terminal region
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- COVID-19
- familial focal epilepsy with variable foci
- hereditary disorder
- gastroesophageal reflux
- familial focal epilepsy with variable foci type 1
- non-insulin-dependent diabetes mellitus
- hepatic steatosis
- chronic hepatitis C
role in cell
- phosphorylation in
- proliferation
- signaling in
- hypertrophy
- growth
- cell cycle progression
- cell viability
- capivasertib resistance
- response by
- taselisib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- lysosome
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Depdc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- cellular response to amino acid starvation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- Cul3-RING ubiquitin ligase complex
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- small GTPase binding