Slc29a1 Gene Summary [Rat]
Enables uridine transmembrane transporter activity. Involved in several processes, including excitatory postsynaptic potential; lactation; and uridine transmembrane transport. Located in basolateral plasma membrane. Is active in postsynapse and presynapse. Used to study brain ischemia. Orthologous to human SLC29A1 (solute carrier family 29 member 1 (Augustine blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc29a1 |
| Official Name | solute carrier family 29 member 1 [Source:RGD Symbol;Acc:61899] |
| Ensembl ID | ENSRNOG00000019752 |
| Bio databases IDs | |
| Aliases | solute carrier family 29 member 1 |
| Synonyms | 1200014D21Rik, AUG, ENT1, hENT1, mENT1, rENT1, solute carrier family 29 member 1, Solute carrier family 29, member 1, solute carrier family 29 member 1 (Augustine blood group), solute carrier family 29 (nucleoside transporters), member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc29a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uridine transporter
- cytidine transporter
- purine nucleoside transporter
- nucleoside transporter
- Equilibrative Nucleoside Transporter (ENT)
- uracil transporter
- pyrimidine- and adenine-specific:sodium symporter
- transmembrane domain
- guanine transporter
- neurotransmitter transporter
- adenine transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic stable angina
- non-insulin-dependent diabetes mellitus
- atrial fibrillation
- disorder of coronary artery
- disorder of artery
- chronic kidney disease
- diabetes mellitus
- cardiovascular disorder
- atherosclerosis
- kidney disease
role in cell
- function
- expression in
- proliferation
- cellular infiltration by
- number
- differentiation
- cell death
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- cell periphery
- intracellular space
- postsynaptic region
- cellular membrane
- Nucleus
- Mitochondria
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc29a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleobase transport
- thymine transport
- uridine transport
- cytidine transport
- regulation of excitatory postsynaptic membrane potential
- purine nucleoside transport
- hypoxanthine transport
- inosine transport
- lactation
- nucleobase-containing compound metabolic process
- neurotransmitter transport
- drug transmembrane transport
- pyrimidine-containing compound transmembrane transport
- cellular response to glucose stimulus
- neurotransmitter uptake
- xenobiotic metabolic process
- nucleoside transport
- cellular response to hypoxia
- adenosine transport
- adenine transport
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleoside transmembrane transporter activity
- pyrimidine- and adenine-specific:sodium symporter activity
- neurotransmitter transporter activity
- uridine transmembrane transporter activity
- cytidine transmembrane transporter activity
- purine nucleoside transmembrane transporter activity
- uracil transmembrane transporter activity
- guanine transmembrane transporter activity
- adenine transmembrane transporter activity