SIPA1L2 Gene Summary [Human]
This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | SIPA1L2 |
| Official Name | signal induced proliferation associated 1 like 2 [Source:HGNC Symbol;Acc:HGNC:23800] |
| Ensembl ID | ENSG00000116991 |
| Bio databases IDs | |
| Aliases | signal induced proliferation associated 1 like 2, spine‐associated RapGAP 2 |
| Synonyms | mKIAA1389, Sersap2, signal-induced proliferation-associated 1 like 2, SPAL2, SPAR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIPA1L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rap/ran-GAP
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- C-terminal domain of SPAR protein
- PDZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- Parkinson disease
- breast cancer
- shoulder impingement syndrome
- idiopathic scoliosis
- schizophrenia
- food allergy
role in cell
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- glutaminergic synapse
- organelle
- presynaptic regions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIPA1L2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity