Prlh Gene Summary [Rat]
Enables neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Involved in G protein-coupled receptor signaling pathway and feeding behavior. Acts upstream of or within reduction of food intake in response to dietary excess. Located in cytoplasm. Used to study obesity. Orthologous to human PRLH (prolactin releasing hormone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prlh |
| Official Name | prolactin releasing hormone [Source:RGD Symbol;Acc:628634] |
| Ensembl ID | ENSRNOG00000019871 |
| Bio databases IDs | |
| Aliases | prolactin releasing hormone |
| Synonyms | EG623503, PRH, prolactin releasing hormone, PRRP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prlh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolactin-releasing peptide
- prolactin receptor binding
- G-protein-coupled receptor binding
- hormone
- neuropeptide hormone
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cellular membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prlh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- G-protein coupled receptor signaling pathway
- energy reserve metabolic process
- feeding behavior
- response to dietary excess
- fat cell differentiation
- response to peptide hormone stimulus
- eating behavior
- tissue homeostasis
- autonomic nervous system development
- response to glucose stimulus
- response to insulin stimulus
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- neuropeptide hormone activity
- prolactin-releasing peptide receptor binding
- hormone activity