Slc4a3 Gene Summary [Rat]
Enables chloride:bicarbonate antiporter activity and enzyme binding activity. Predicted to be involved in several processes, including bicarbonate transport; regulation of cardiac muscle cell action potential; and regulation of pH. Predicted to act upstream of or within cardiac conduction. Located in plasma membrane. Orthologous to human SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc4a3 |
| Official Name | solute carrier family 4 member 3 [Source:RGD Symbol;Acc:3712] |
| Ensembl ID | ENSRNOG00000020138 |
| Bio databases IDs | |
| Aliases | solute carrier family 4 member 3 |
| Synonyms | A930038D23RIK, AE3, Aep3, CAE3/BAE3, SLC2C, solute carrier family 4 (anion exchanger), member 3, solute carrier family 4 member 3, SQT7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc4a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HCO3- transporter family
- Band 3 cytoplasmic domain
- antiporter
- enzyme binding
- protein binding
- anion exchange protein
- chloride transporter
- inorganic anion exchanger
- bicarbonate transporter
- transporter
- anion transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- short QT syndrome 7
- seizures
- androgenic alopecia
- short QT syndrome
- blindness
- structural anomaly
role in cell
- expression in
- apoptosis
- abnormal morphology
- action potential by
- action potential
- disorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc4a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of intracellular pH
- regulation of cardiac muscle cell action potential
- transmembrane transport
- pH reduction
- bicarbonate transport
- cardiac conduction
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane transporter activity
- inorganic anion exchanger activity
- bicarbonate transmembrane transporter activity