Rangap1 Gene Summary [Rat]
Enables small GTPase binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to vasopressin and response to axon injury. Located in several cellular components, including axon cytoplasm; cytoplasmic periphery of the nuclear pore complex; and mitotic spindle. Part of nuclear pore cytoplasmic filaments. Biomarker of sciatic neuropathy. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rangap1 |
| Official Name | RAN GTPase activating protein 1 [Source:RGD Symbol;Acc:1310380] |
| Ensembl ID | ENSRNOG00000031789 |
| Bio databases IDs | |
| Aliases | RAN GTPase activating protein 1 |
| Synonyms | Fug1, mKIAA1835, RANGAP, RAN GTPase activating protein 1, SD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rangap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein phosphatase 1 regulatory subunit 42
- RanGAP1 C-terminal domain
- Leucine rich repeat, ribonuclease inhibitor type
- enzyme binding
- GTPase activator
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rangap1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- neoplasia
- liver cancer
- epithelial cancer
- metastasis
- hepatocellular carcinoma
- allergy
role in cell
- growth
- migration
- invasion by
- binding in
- maturation
- attachment
- nuclear export in
- attachment in
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- aggresome
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- spindle pole bodies
- cytosol
- nuclear pores
- inner nuclear membrane
- nuclear rim
- nuclear envelope
- cellular protrusions
- mitotic spindle
- kinetochores
- dendrites
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rangap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- negative regulation of protein export from nucleus
- nuclear export
- protein sumoylation
- signal transduction
- response to axon injury
Cellular Component
Where in the cell the gene product is active
- kinetochore
- nucleoplasm
- nuclear pore
- nuclear envelope
- nucleus
- dendrite
- nuclear membrane
- perinuclear region of cytoplasm
- mitotic spindle
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- aggresome
Molecular Function
What the gene product does at the molecular level
- RNA binding
- ubiquitin protein ligase binding
- protein binding
- cadherin binding
- GTPase activator activity
- small GTPase binding