Ank1 Gene Summary [Rat]
Predicted to enable several functions, including enzyme binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in positive regulation of organelle organization. Located in several cellular components, including axolemma; sarcolemma; and sarcomere. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ank1 |
| Official Name | ankyrin 1 [Source:RGD Symbol;Acc:1309620] |
| Ensembl ID | ENSRNOG00000018241 |
| Bio databases IDs | |
| Aliases | ankyrin 1 |
| Synonyms | ANK, ankyrin-1, ankyrin 1, erythroid, ANKYRIN R, nb, pale, SPH1, SPH2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ank1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- Ankyrin repeats (many copies)
- protein phosphatase binding
- Ankyrin repeats (3 copies)
- spectrin binding
- enzyme binding
- protein binding
- zDHHC ankyrin repeat binding domain
- UPA domain
- ZU5 domain
- Ankyrin repeat
- cytoskeletal adaptor
- ATPase binding
- structural constituent of cytoskeleton
- transmembrane domain
- Death Domain Superfamily of protein-protein interaction domains
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Ank1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- non-insulin-dependent diabetes mellitus
- Crohn disease
- heart failure
- neoplasia
- diabetic retinopathy
- Parkinson disease
- spherocytosis type 1
- pervasive developmental disorder
- hypertension
role in cell
- production in
- spare respiratory capacity
- stabilization
- docetaxel resistance
- budding
- polarity
- organization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cortical cytoskeleton
- cytoskeleton
- Cytoplasm
- cellular membrane
- membrane skeleton
- Nucleus
- sarcoplasmic reticulum
- sarcomere
- cytosol
- cytoplasmic face of plasma membrane
- postsynaptic membrane
- Golgi membrane
- nuclear scaffolds
- axonal membrane
- m-bands
- sarcolemma
- myoplasm
- Z line
- erythrocyte membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ank1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- cytoskeleton organization
- maintenance of epithelial cell apical/basal polarity
- signal transduction
- positive regulation of organelle organization
- exocytosis
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum
- neuron projection
- plasma membrane
- internal side of plasma membrane
- Z disc
- cytoskeleton
- postsynaptic membrane
- sarcolemma
- cytosol
- axolemma
- M band
- basolateral plasma membrane
- spectrin-associated cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- cytoskeletal adaptor activity
- protein binding
- spectrin binding
- structural molecule activity
- structural constituent of cytoskeleton
- ion channel binding
- enzyme binding
- ATPase binding