Taf13 Gene Summary [Rat]
Predicted to enable DNA binding activity and TBP-class protein binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 60. Orthologous to human TAF13 (TATA-box binding protein associated factor 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf13 |
| Official Name | TATA-box binding protein associated factor 13 [Source:RGD Symbol;Acc:1305398] |
| Ensembl ID | ENSRNOG00000020315 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 13 |
| Synonyms | 1810004N01Rik, 2010309N11Rik, MRT60, TAF2K, TAF(II)18, TAFII-18, TATA-box binding protein associated factor 13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Taf13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- histone fold domain (HFD) superfamily
- transcription regulator
- protein binding
- TATA-binding protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Taf13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- melanoma cancer
- autosomal recessive mental retardation type 60
- adenoma formation
- Alzheimer disease
- melanoma
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- schizophrenia
- glioblastoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Taf13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- transcription initiation, DNA-dependent
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- TBP-class protein binding