Taf4

Predicted to enable DNA binding activity and aryl hydrocarbon receptor binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity and core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Predicted to act upstream of or within DNA-templated transcription and ovarian follicle development. Predicted to be located in chromatin; cytosol; and nucleus. Predicted to be part of MLL1 complex; transcription factor TFIID complex; and transcription factor TFTC complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 73. Orthologous to human TAF4 (TATA-box binding protein associated factor 4). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Taf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Taf4 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Taf4 gene, providing context for its role in the cell.