Vav3 Gene Summary [Rat]
Predicted to enable epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within several processes, including integrin-mediated signaling pathway; lamellipodium assembly; and neutrophil chemotaxis. Predicted to be located in immunological synapse. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vav3 |
| Official Name | vav guanine nucleotide exchange factor 3 [Source:RGD Symbol;Acc:1565941] |
| Ensembl ID | ENSRNOG00000020485 |
| Bio databases IDs | |
| Aliases | vav guanine nucleotide exchange factor 3 |
| Synonyms | A530094I06Rik, Idd18.1, RGD1565941, vav 3 oncogene, vav guanine nucleotide exchange factor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vav3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- epidermal growth factor receptor binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- cytokine
- acidic domain
- RhoGEF domain
- Src Homology 3 domain superfamily
- RhoGEF
- protein kinase C conserved region 1 (C1 domain) superfamily
- guanyl-nucleotide exchange factor
- calponin homology (CH) domain superfamily
- PH domain
- Src homology 2 (SH2) domain
- zinc finger domain
- guanine nucleotide exchange factor domain
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Vav3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- B Cell Receptor Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G Protein Signaling Mediated by Tubby
- Gα12/13 Signaling
- Leukocyte Extravasation Signaling
- Natural Killer Cell Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- T Cell Receptor Signaling
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- hypertension
- neoplasia
- abdominal cancer
- digestive system cancer
- thyroid disease
- experimentally induced airway hyperresponsiveness
- epithelial thyroid cancer
- tumorigenesis
- IgA nephropathy
role in cell
- apoptosis
- activation in
- production in
- growth
- expression in
- colony formation
- binding in
- invasion by
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Plasma Membrane
- immunological synapses
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vav3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- regulation of cell size
- Fc-epsilon receptor signaling pathway
- response to xenobiotic stimulus
- Fc-gamma receptor signaling pathway involved in phagocytosis
- positive regulation of cell adhesion
- response to DNA damage stimulus
- integrin-mediated signaling pathway
- angiogenesis
- vesicle fusion
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- lamellipodium assembly
- positive regulation of B cell proliferation
- neutrophil chemotaxis
- cell migration
- platelet activation
- positive regulation of protein kinase B signaling cascade
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- epidermal growth factor receptor binding