Cyp2s1 Gene Summary [Rat]
Predicted to enable several functions, including heme binding activity; monooxygenase activity; and thromboxane-A synthase activity. Predicted to be involved in monocarboxylic acid metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human CYP2S1 (cytochrome P450 family 2 subfamily S member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp2s1 |
| Official Name | cytochrome P450, family 2, subfamily s, polypeptide 1 [Source:RGD Symbol;Acc:1306078] |
| Ensembl ID | ENSRNOG00000020743 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 2, subfamily s, polypeptide 1 |
| Synonyms | 1200011C15Rik, CYPIIS1, cytochrome P450 family 2 subfamily S member 1, cytochrome P450, family 2, subfamily s, polypeptide 1, LOC687052 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp2s1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- unspecific monooxygenase
- thromboxane-A synthase
- retinoic acid 4-hydroxylase
- hydro-lyase
- monooxygenase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Cyp2s1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- nasal polyp
- head and neck neoplasia
- systemic lupus erythematosus
- disorder of the nose
regulates
- eicosanoid
- reporter gene
- cytochrome
- tretinoin
- CYP2S1
- prostaglandin
role in cell
- proliferation
- migration
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp2s1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epoxygenase P450 pathway
- icosanoid metabolic process
- xenobiotic metabolic process
- retinoic acid metabolic process
- prostaglandin metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- arachidonic acid epoxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- 12-hydroxyheptadecatrienoic acid synthase activity
- protein binding
- hydro-lyase activity
- iron ion binding
- retinoic acid 4-hydroxylase activity
- monooxygenase activity
- heme binding
- thromboxane-A synthase activity