Arvcf Gene Summary [Rat]
Predicted to enable cadherin binding activity. Predicted to be involved in RNA splicing and cell-cell adhesion. Predicted to be located in anchoring junction. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in DiGeorge syndrome. Orthologous to human ARVCF (ARVCF delta catenin family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arvcf |
| Official Name | ARVCF, delta catenin family member [Source:RGD Symbol;Acc:1306655] |
| Ensembl ID | ENSRNOG00000001888 |
| Bio databases IDs | |
| Aliases | ARVCF, delta catenin family member |
| Synonyms | armadillo repeat gene deleted in velocardiofacial syndrome, ARVCF delta catenin family member, ARVCF, delta catenin family member, ARVCF δ catenin family member, ARVCF, δ catenin family member, LOC680480, LOC682600 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arvcf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- HEAT-like repeat
- Armadillo/beta-catenin-like repeats
- cadherin binding
- protein binding
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Raynaud disease
- schizophrenia
- Alzheimer disease
- coronary artery disease
- COVID-19
role in cell
- apoptosis
- adhesion
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
- cell-cell contacts
- granules
- nucleoplasm
- nucleoli
- growth cone
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arvcf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- cell adhesion
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- adherens junction
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding