Lin7b Gene Summary [Rat]
Enables PDZ domain binding activity and protein kinase binding activity. Predicted to be involved in neurotransmitter secretion; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle transport. Located in cell-cell junction. Is active in postsynaptic density, intracellular component. Orthologous to human LIN7B (lin-7 homolog B, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lin7b |
| Official Name | lin-7 homolog B, crumbs cell polarity complex component [Source:RGD Symbol;Acc:620730] |
| Ensembl ID | ENSRNOG00000020746 |
| Bio databases IDs | |
| Aliases | lin-7 homolog B, crumbs cell polarity complex component |
| Synonyms | lin-7 homolog B, crumbs cell polarity complex component, MALS-2, VELI1A, VELI2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lin7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase binding
- canonical PDZ domain
- protein domain specific binding
- protein binding
- PDZ domain
- PDZ-domain binding
- L27 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoplasmic vesicle membrane
- organelle
- cellular membrane
- Plasma Membrane
- intercellular junctions
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lin7b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of epithelial cell apical/basal polarity
- protein transport
- exocytosis
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- MPP7-DLG1-LIN7 complex
- tight junction
- cell-cell junction
- synapse
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- protein binding
- L27 domain binding
- PDZ domain binding