Asic3 Gene Summary [Rat]
Enables pH-gated calcium channel activity and pH-gated sodium channel activity. Involved in detection of chemical stimulus involved in sensory perception of pain; membrane depolarization; and monoatomic ion transmembrane transport. Acts upstream of or within response to acidic pH and sodium ion transport. Located in perinuclear region of cytoplasm. Is active in plasma membrane. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asic3 |
| Official Name | acid sensing ion channel subunit 3 [Source:RGD Symbol;Acc:708578] |
| Ensembl ID | ENSRNOG00000008380 |
| Bio databases IDs | |
| Aliases | acid sensing ion channel subunit 3 |
| Synonyms | ACCN3, acid-sensing ion channel 3, acid sensing ion channel subunit 3, DRASIC, SLNAC1, TNAC1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Asic3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium channel
- calcium channel
- amiloride-sensitive sodium channel
- sodium channel transporter
- enterobactin transporter
- ligand-gated ion channel
- protein binding
- nonproton ligand sensing domain
- PDZ binding motif
- ion channel
- cation channel
Pathways
Biological processes and signaling networks where the Asic3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- congestive heart failure
- hypertension
- essential hypertension
- sleep apnea syndrome
- disorder of coronary artery
- edema
- chronic kidney disease
- cardiovascular disorder
- proteinuria
role in cell
- degeneration
- transmembrane potential
- depolarization
- electrophysiology
- stimulation in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- Cytoplasm
- intracellular space
- perinuclear region
- cellular membrane
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Asic3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to heat
- signal transduction
- sensory perception of sour taste
- detection of chemical stimulus involved in sensory perception of pain
- detection of mechanical stimulus involved in sensory perception of pain
- sodium ion transmembrane transport
- response to acidity
- establishment of localization in cell
- detection of temperature stimulus involved in sensory perception of pain
- enterobactin transport
- sensory perception
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium channel activity
- cation channel activity
- ligand-gated sodium channel activity
- enterobactin transporter activity