Kcnj4 Gene Summary [Rat]
Enables inward rectifier potassium channel activity. Involved in cellular response to mechanical stimulus. Located in dendrite and neuronal cell body. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnj4 |
| Official Name | potassium inwardly-rectifying channel, subfamily J, member 4 [Source:RGD Symbol;Acc:621436] |
| Ensembl ID | ENSRNOG00000013869 |
| Bio databases IDs | |
| Aliases | potassium inwardly-rectifying channel, subfamily J, member 4 |
| Synonyms | HIR, HIRK2, HRK1, IRK-3, Kcnf2, Kir2.3, MB-IRK3, potassium inwardly rectifying channel subfamily J member 4, potassium inwardly-rectifying channel, subfamily J, member 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnj4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inward rectifier potassium channel
- cytoplasmic domain
- Inward rectifier potassium channel C-terminal domain
- Inward rectifier potassium channel transmembrane domain
- protein binding
- PDZ binding motif
- ion channel
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Kcnj4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cellular membrane
- postsynaptic membrane
- basolateral membrane
- perikaryon
- dendrites
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnj4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- regulation of ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- postsynaptic membrane
- voltage-gated potassium channel complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- PDZ domain binding
- inward rectifier potassium channel activity