Sult2b1 Gene Summary [Rat]
Predicted to enable nucleic acid binding activity; steroid binding activity; and steroid sulfotransferase activity. Predicted to be involved in several processes, including 3'-phosphoadenosine 5'-phosphosulfate metabolic process; positive regulation of epidermal cell differentiation; and sulfation. Predicted to act upstream of or within sulfate assimilation. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14. Orthologous to human SULT2B1 (sulfotransferase family 2B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sult2b1 |
| Official Name | sulfotransferase family 2B member 1 [Source:RGD Symbol;Acc:1308882] |
| Ensembl ID | ENSRNOG00000021046 |
| Bio databases IDs | |
| Aliases | sulfotransferase family 2B member 1 |
| Synonyms | ARCI14, HSST2, ST2B1, sulfotransferase family 2B member 1, sulfotransferase family, cytosolic, 2B, member 1, sulphotransferase family 2B member 1, sulphotransferase family, cytosolic, 2B, member 1, SULT2B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sult2b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- sulfotransferase
- cholesterol binding
- steroid sulfotransferase
- binding protein
- nucleic acid binding
- Sulfotransferase domain
- enzyme
- protein binding
- Sulfotransferase family
- steroid binding
Pathways
Biological processes and signaling networks where the Sult2b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive congenital ichthyosis type 14
- psoriasis
- retinal hemorrhage
- colorectal carcinoma
- colorectal carcinomagenesis
- autosomal recessive congenital ichthyosis type 2
- colon cancer
- pancreatic neoplasia
- juvenile dermatomyositis
- preeclampsia
regulated by
- GW501516
- beta-estradiol
- HNF4A
- 5-cholesten-3beta,25-diol 3-sulfonic acid
- actinomycin D
- BIM5078
- 25-hydroxycholesterol
- T lymphocytes
- clofibrate
- 22(R)-hydroxycholesterol
role in cell
- expression in
- production in
- quantity
- apoptosis
- cell viability
- proliferation
- differentiation
- invasion
- S phase
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sult2b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of epidermal cell differentiation
- negative regulation of cell proliferation
- cholesterol metabolic process
- steroid metabolic process
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- sulfation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- cholesterol binding
- steroid sulfotransferase activity
- small molecule binding
- sulfotransferase activity
- cholesterol sulfotransferase activity