Cyth2 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and inositol 1,4,5 trisphosphate binding activity. Involved in negative regulation of dendrite development. Located in ruffle. Is extrinsic component of postsynaptic specialization membrane. Orthologous to human CYTH2 (cytohesin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyth2 |
| Official Name | cytohesin 2 [Source:RGD Symbol;Acc:620398] |
| Ensembl ID | ENSRNOG00000021051 |
| Bio databases IDs | |
| Aliases | cytohesin 2 |
| Synonyms | ARNO, CLM2, CTS18, CTS18.1, cytohesin-2, LOC284356, PSCD2, PSCD2L, Sec7, Sec7B, SEC7L, Sec7p-L, Sec7p-like |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyth2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- binding protein
- polybasic region
- Sec7
- Sec7 domain
- guanyl-nucleotide exchange factor
- PH domain
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- C-terminal extension
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- IgA nephropathy
- hypersensitivity reaction type I
role in cell
- expression in
- activation in
- degradation in
- motility
- accumulation in
- migration
- number
- cell spreading
- development
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- ruffle
- postsynaptic region
- cellular membrane
- Plasma Membrane
- endosomes
- cytosol
- Golgi membrane
- neurites
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyth2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
- endocytosis
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- growth cone
- adherens junction
- tight junction
- cytoplasm
- membrane
- cytosol
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- lipid binding
- inositol 1,4,5 trisphosphate binding