Fkbp6 Gene Summary [Rat]
Predicted to enable Hsp90 protein binding activity and identical protein binding activity. Involved in spermatogenesis. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nuclear lumen. Predicted to be active in cytoplasm. Used to study male infertility. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure 77. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fkbp6 |
| Official Name | FKBP prolyl isomerase 6 [Source:RGD Symbol;Acc:1308926] |
| Ensembl ID | ENSRNOG00000001451 |
| Bio databases IDs | |
| Aliases | FKBP prolyl isomerase 6 |
| Synonyms | 1700008G22Rik, D5Ertd724e, FK506 binding protein 6, FKBP-36, FKBP prolyl isomerase family member 6, FKBP prolyl isomerase family member 6 (inactive), PPIase, SPGF77 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fkbp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FKBP-type peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
- FK506 binding
- heat shock protein binding
- enzyme
- protein binding
- identical protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- fibrillar center
- Cytoplasm
- cytoplasmic bridges
- cytosol
- nucleoplasm
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fkbp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- spermatogenesis
- cell differentiation
- gene silencing by RNA
- piRNA metabolic process
- protein folding
- positive regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- identical protein binding
- protein binding
- FK506 binding
- Hsp90 protein binding