Pex11b Gene Summary [Rat]
Predicted to enable protein homodimerization activity. Predicted to be involved in peroxisome fission and regulation of peroxisome size. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 14B. Orthologous to human PEX11B (peroxisomal biogenesis factor 11 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex11b |
| Official Name | peroxisomal biogenesis factor 11 beta [Source:RGD Symbol;Acc:1310353] |
| Ensembl ID | ENSRNOG00000021216 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 11 beta |
| Synonyms | LOC101060567, Peroxin-11B, peroxisomal biogenesis factor 11 beta, peroxisomal biogenesis factor 11 β, PEX11-BETA, Pex11betap, Pex11pbeta, PEX11-β, Pex11βp, PEX14B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pex11b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine rich domain
- Peroxisomal biogenesis factor 11 (PEX11)
- amphipathic helix
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- intellectual disability and developmental delay
- hypotonia
- infantile refsum disease
- peroxisome biogenesis disorder 14B
- developmental delay
- peroxisome biogenesis disorder
regulates
- glycogen
- ether lipid
- DNM1L
- peroxisome
role in cell
- migration
- apoptosis
- differentiation
- proliferation
- quantity
- elongation
- organization
- fission
- elongation in
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Mitochondria
- cytosol
- peroxisome membrane
- nucleoplasm
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pex11b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peroxisome fission
- signal transduction
- regulation of peroxisome size
- peroxisome organization
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity