Homer1

Enables several functions, including identical protein binding activity; scaffold protein binding activity; and type 5 metabotropic glutamate receptor binding activity. A structural constituent of postsynapse. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; protein tetramerization; and regulation of dendritic spine maintenance. Located in dendrite; excitatory synapse; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Homer1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Homer1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Homer1 gene, providing context for its role in the cell.