Rft1 Gene Summary [Rat]
Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process and glycolipid translocation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation In. Orthologous to human RFT1 (RFT1 homolog). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rft1 |
| Official Name | RFT1 homolog [Source:RGD Symbol;Acc:1562654] |
| Ensembl ID | ENSRNOG00000021805 |
| Bio databases IDs | |
| Aliases | RFT1 homolog |
| Synonyms | CDG1N, D930025H04, LOC285398, RFT1 glycolipid translocator homolog, RFT1 homolog, RGD1562654 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rft1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- Multidrug and toxic compound extrusion family and similar proteins
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 1N
- pervasive developmental disorder
- non-insulin-dependent diabetes mellitus
- Crohn disease
- multiple sclerosis
- metabolic syndrome X
regulated by
- myoblasts
regulates
- oligosaccharide-diphosphodolichol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rft1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation
- glycolipid translocation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- glycolipid-translocating activity