Htr1b Gene Summary [Rat]
Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including drinking behavior; modulation of chemical synaptic transmission; and regulation of amine transport. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr1b |
| Official Name | 5-hydroxytryptamine receptor 1B [Source:RGD Symbol;Acc:2846] |
| Ensembl ID | ENSRNOG00000013042 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 1B |
| Synonyms | 5-HT-1B, 5-HT1DB, 5-HT-1D-beta, 5HT1D beta receptor, 5-HT-1D-β, 5HT1D β receptor, 5HTR1B, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine (serotonin) receptor 1B, HTR1D2, HTR1DB, S12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Htr1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- voltage-gated calcium channel
- intracellular loop
- 5-HT1 receptor
- binding protein
- cytoplasmic domain
- serotonin receptor
- serotonin binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Htr1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- obesity
- migraine with or without aura
- epileptic encephalopathy
- migraine with aura
- cluster headache
- migraines
- Huntington disease
- migraine without aura
- schizophrenia
role in cell
- quantity
- binding in
- internalization in
- binding
- number
- firing
- transmission
- response by
- patterning
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- presynaptic membrane
- synapse
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Htr1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- drinking behavior
- regulation of dopamine secretion
- bone remodeling
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
- negative regulation of gamma-aminobutyric acid secretion
- negative regulation of serotonin secretion
- response to cocaine
- synaptic transmission
- G-protein coupled receptor internalization
- vasoconstriction
- protein kinase C-activating G-protein coupled receptor signaling pathway
- regulation of behavior
- response to ethanol
- negative regulation of synaptic transmission, GABAergic
- response to mineralocorticoid stimulus
- regulation of synaptic vesicle exocytosis
- cellular response to temperature stimulus
- cellular response to xenobiotic stimulus
- negative regulation of synaptic transmission, glutamatergic
- cellular response to alkaloid
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- endoplasmic reticulum
- plasma membrane
- calyx of Held
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- protein binding
- neurotransmitter receptor activity
- serotonin receptor activity