Tecr Gene Summary [Rat]
Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in fatty acid elongation; sphingolipid metabolic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14. Orthologous to human TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tecr |
| Official Name | trans-2,3-enoyl-CoA reductase [Source:RGD Symbol;Acc:620376] |
| Ensembl ID | ENSRNOG00000021808 |
| Bio databases IDs | |
| Aliases | trans-2,3-enoyl-CoA reductase |
| Synonyms | 2410016D23Rik, A230102P12Rik, D17Ertd178e, GPSN2, MRT14, SC2, TER, trans-2,3-enoyl-CoA reductase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tecr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-oxo-5-alpha-steroid 4-dehydrogenase
- CH-CH group:NAD or NADP oxidoreductase
- Ubl1_cv_Nsp3_N-like
- enzyme
- protein binding
- very-long-chain acyl-CoA dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early onset hypertension
- celiac disease
- androgenic alopecia
- mental retardation
- autosomal recessive mental retardation type 14
- autosomal recessive nonsyndromic mental retardation
- nonsyndromic mental retardation
- productive infection by HIV-1
role in cell
- conversion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tecr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty-acyl-CoA biosynthetic process
- fatty acid elongation
- very long-chain fatty acid biosynthetic process
- sphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- very-long-chain-acyl-CoA dehydrogenase activity