Scx Gene Summary [Rat]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Scx |
| Official Name | scleraxis bHLH transcription factor [Source:RGD Symbol;Acc:1588254] |
| Ensembl ID | ENSRNOG00000021812 |
| Bio databases IDs | |
| Aliases | scleraxis bHLH transcription factor |
| Synonyms | BB114693, bHLHa41, bHLHa48, LOC684826, Scl, scleraxis bHLH transcription factor, scleraxis scleraxis bHLH transcription factor, SCXA, SCXB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
role in cell
- proliferation
- apoptosis
- differentiation
- organization
- endochondral ossification by
- disarray
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sclerotome development
- regulation of cartilage development
- positive regulation of cartilage development
- positive regulation of cell proliferation
- Sertoli cell differentiation
- chondrocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- heart valve morphogenesis
- face morphogenesis
- positive regulation of collagen biosynthetic process
- negative regulation of transcription, DNA-dependent
- skeletal muscle cell differentiation
- positive regulation of transcription, DNA-dependent
- BMP signaling pathway
- mesoderm formation
- developmental process
- tendon cell differentiation
- tendon formation
- deltoid tuberosity development
- transcription, DNA-dependent
- heart valve formation
- embryonic skeletal system development
- regulation of transcription from RNA polymerase II promoter
- tissue homeostasis
- cellular response to transforming growth factor beta stimulus
- cellular response to mechanical stimulus
- positive regulation of gene expression
- negative regulation of apoptotic process
- positive regulation of gastrulation
- cell differentiation
- endochondral ossification
- tendon development
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- bHLH transcription factor binding
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity