Ccr8 Gene Summary [Rat]
Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemotaxis. Predicted to be active in external side of plasma membrane. Biomarker of asthma and pulmonary fibrosis. Orthologous to human CCR8 (C-C motif chemokine receptor 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr8 |
| Official Name | C-C motif chemokine receptor 8 [Source:RGD Symbol;Acc:1304893] |
| Ensembl ID | ENSRNOG00000026759 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine receptor 8 |
| Synonyms | C-C, C-C CKR-8, C-C motif chemokine receptor 8, CDw198, CHEMOKINE CC8 receptor, CKR-8, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, mCCR8, TER1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccr8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- coreceptor
Pathways
Biological processes and signaling networks where the Ccr8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eosinophilia
- cancer
- metastasis
- advanced cancer
- insulin-dependent diabetes mellitus
- early missed abortion
- lymphatic metastasis
- eosinophilic esophagitis
- colorectal adenocarcinoma
- colorectal carcinomagenesis
role in cell
- expression in
- apoptosis
- migration
- quantity
- growth
- adhesion
- activation
- recruitment
- trafficking
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccr8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- immune response
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- cell adhesion
- calcium-mediated signaling
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- coreceptor activity
- C-C chemokine receptor activity
- chemokine receptor activity