Tcf7l1 Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in canonical Wnt signaling pathway and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including axial mesoderm morphogenesis; regulation of DNA-templated transcription; and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in chromatin. Orthologous to human TCF7L1 (transcription factor 7 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcf7l1 |
| Official Name | transcription factor 7 like 1 [Source:RGD Symbol;Acc:1311671] |
| Ensembl ID | ENSRNOG00000014753 |
| Bio databases IDs | |
| Aliases | transcription factor 7 like 1 |
| Synonyms | bHLHb21, LOC100361823, TCF-3, transcription factor 7 like 1, transcription factor 7 like 1 (T cell specific, HMG box) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tcf7l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- beta-catenin binding
- high mobility group (HMG)-box domain superfamily
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- double-stranded DNA binding
- N-terminal CTNNB1 binding
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- transcription factor activity
Pathways
Biological processes and signaling networks where the Tcf7l1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Opioid Signaling Pathway
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PEDF Signaling
- Protein Kinase A Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Thyroid Cancer Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
- bone cancer
- chronic obstructive pulmonary disease
- microphthalmia
- chordoma
- breast cancer
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- anophthalmia
role in cell
- phosphorylation in
- proliferation
- survival
- expression in
- cell viability
- binding in
- differentiation
- self-renewal
- downregulation in
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tcf7l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- canonical Wnt receptor signaling pathway
- regulation of transcription, DNA-dependent
- regulation of Wnt receptor signaling pathway
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity