FGF5
FGF5 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGF5 |
| Official Name | fibroblast growth factor 5 [Source:HGNC Symbol;Acc:HGNC:3683] |
| Ensembl ID | ENSG00000138675 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 5 |
| Synonyms | angora,Fgf3a,fibroblast growth factor 5,go,HBGF-5,Smag-82,TCMGLY |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nerve growth factor receptor binding
- beta-trefoil_FGF
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the FGF5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EZH2
- FGFR1
- histone H3
- heparin
- SUZ12
- JARID2
- Fibrinogen
- EED
- histone H2A
- FGFR2
disease
- major depression
- glioblastoma
- glioblastoma cancer
- alopecia
- glioma formation
- male pattern hair loss
- androgenic alopecia
- colorectal cancer
- angina pectoris
- trichomegaly
regulated by
- KRAS
- 8-bromo-cAMP
- estrogen receptor
- RELA
- POU5F1
- embryonic stem cells
- ciglitazone
- TCF7L1
- tretinoin
- MYCN
regulates
- Ca2+
- RAF1
- NFkB (complex)
- RAS
- FRS2
- CSF3
- FGFR2
- FGFR1
- MAPK1
- phosphatidylinositol
role in cell
- differentiation
- expression in
- proliferation
- migration
- apoptosis
- morphology
- growth
- phosphorylation in
- survival
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FGF5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- signal transduction involved in regulation of gene expression
- nervous system development
- cell-cell signaling
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- organ morphogenesis
- positive regulation of cell division
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of cell migration
- glial cell differentiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor activity
- fibroblast growth factor receptor binding