Cnih3 Gene Summary [Rat]
Enables channel regulator activity. Involved in regulation of AMPA receptor activity. Acts upstream of or within glutamatergic synaptic transmission and regulation of membrane potential. Located in dendritic shaft and postsynaptic membrane. Part of AMPA glutamate receptor complex. Orthologous to human CNIH3 (cornichon family AMPA receptor auxiliary protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnih3 |
| Official Name | cornichon family AMPA receptor auxiliary protein 3 [Source:RGD Symbol;Acc:1582859] |
| Ensembl ID | ENSRNOG00000022724 |
| Bio databases IDs | |
| Aliases | cornichon family AMPA receptor auxiliary protein 3 |
| Synonyms | 2900075G08Rik, cornichon family AMPA receptor auxiliary protein 3, LOC682727 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cnih3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cornichon protein
- channel regulator
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- vesicles
- endoplasmic reticulum membrane
- postsynaptic membrane
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cnih3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- dendrite
- postsynaptic membrane
- dendritic shaft
- ER to Golgi transport vesicle membrane
- synapse
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding