Traf4 Gene Summary [Rat]
Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of protein kinase activity; and regulation of intracellular signal transduction. Predicted to act upstream of or within respiratory gaseous exchange by respiratory system and respiratory tube development. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human TRAF4 (TNF receptor associated factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Traf4 |
| Official Name | Tnf receptor associated factor 4 [Source:RGD Symbol;Acc:1306708] |
| Ensembl ID | ENSRNOG00000013169 |
| Bio databases IDs | |
| Aliases | Tnf receptor associated factor 4 |
| Synonyms | A530032M13Rik, CART1, MLN62, msp2, RNF83, TNF receptor associated factor 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Traf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p47phox binding domain
- ubiquitin protein ligase binding
- MATH
- protein kinase binding
- tumor necrosis factor receptor binding
- CTD TRAF subdomain
- enzyme binding
- WW domain binding
- coiled-coil domain
- TRAF domain
- protein binding
- identical protein binding
- TRAF-type zinc finger
- beta strand or sheet
- PxxY motif
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Traf4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- metastasis
- prostate cancer
- tumorigenesis
- organismal death
- spina bifida
- colorectal cancer
- stenosis
- castration refractory prostate cancer
role in cell
- phosphorylation in
- migration
- activation in
- proliferation
- expression in
- invasion by
- binding in
- colony formation
- radiosensitivity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- fibrillar center
- perinuclear region
- Nucleus
- cytosol
- basal cell surfaces
- nucleoplasm
- detergent-soluble fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Traf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- signal transduction
- positive regulation of protein kinase activity
- innate immune response
- positive regulation of JNK cascade
- apoptotic process
- regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptotic process
- respiratory gaseous exchange
- respiratory tube development
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- perinuclear region of cytoplasm
- cytoskeleton
- cytoplasm
- cytosol
- plasma membrane
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- zinc ion binding
- protein binding
- ubiquitin protein ligase binding
- tumor necrosis factor receptor binding
- transferase activity
- thioesterase binding
- WW domain binding