Tspan2 Gene Summary [Mouse]
Acts upstream of or within inflammatory response and nervous system development. Located in myelin sheath and plasma membrane. Is expressed in pituitary gland. Orthologous to human TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan2 |
| Official Name | tetraspanin 2 [Source:MGI Symbol;Acc:MGI:1917997] |
| Ensembl ID | ENSMUSG00000027858 |
| Bio databases IDs | |
| Aliases | tetraspanin 2 |
| Synonyms | 6330415F13Rik, B230119D02Rik, NET3, tetraspanin 2, TSN2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding
- Tetraspanin family
Pathways
Biological processes and signaling networks where the Tspan2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- schizophrenia
- demyelination
- astrocytosis
- paralysis
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- microgliosis
- preeclampsia
- kyphosis
role in cell
- apoptosis
- formation
- activation in
- degeneration
- development
- differentiation
- myelination
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Plasma Membrane
- nucleoplasm
- myelin sheath
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- astrocyte development
- inflammatory response
- myelination
- microglia development
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding