Lepr Gene Summary [Rat]
Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of behavior; and positive regulation of cell communication. Located in extracellular space. Used to study several diseases, including chronic kidney disease; congestive heart failure (multiple); glucose metabolism disease (multiple); obesity; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Lepr |
| Official Name | leptin receptor [Source:RGD Symbol;Acc:3001] |
| Ensembl ID | ENSRNOG00000023664 |
| Bio databases IDs | |
| Aliases | leptin receptor |
| Synonyms | CD295, db, diabetes, Fa, LEPROT, leptin receptor, LEPTIN receptor splice variant form 13.2, Modb1, obese-like, obl, OB-R, Ob-re, OB receptor, OB-RGRP, Ob-RM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lepr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ig-like C2-type domain
- extracellular domain
- Box motif
- immunoglobulin domain
- Obesity receptor immunoglobulin like domain
- protein binding
- Fibronectin type 3 domain
- identical protein binding
- polypeptide hormone binding
- phosphotyrosine motif
- YXXP domain
- cytokine receptor homology domain
- Box I domain
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- protein-hormone receptor
- STAT3 binding domain
- cytokine receptor
- transmembrane receptor
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Lepr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ischemic stroke
- weight gain
- epithelial cancer
- epithelial neoplasia
- cancer
- digestive system cancer
- abdominal cancer
- adenoma formation
- benign neoplasia
regulated by
- insulin
- monocyte-derived macrophages
- N-ethylmaleimide
- tetradecanoylphorbol acetate
- beta-estradiol
- mir-21 (includes others)
- lipopolysaccharide
- IL33
- IUB288
- growth hormone
role in cell
- apoptosis
- activation in
- phosphorylation in
- expression in
- proliferation
- migration
- loss in
- quantity
- transcription in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- perinuclear region
- intracellular membranes
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- cytosol
- apical cell surfaces
- trans Golgi network
- early endosomes
- extracellular matrix
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lepr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- leptin-mediated signaling pathway
- multicellular organismal development
- energy reserve metabolic process
- cholesterol metabolic process
- response to leptin stimulus
- negative regulation of gluconeogenesis
- cell surface receptor signaling pathway
- regulation of feeding behavior
- T cell differentiation
- regulation of transport
- glycogen metabolic process
- angiogenesis
- regulation of bone remodeling
- cytokine-mediated signaling pathway
- negative regulation of autophagy
- glucose homeostasis
- positive regulation of protein phosphorylation
- energy homeostasis
- phagocytosis
- glial cell proliferation
- sexual reproduction
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- extracellular region
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- leptin receptor activity
- cytokine receptor activity
- cytokine binding