Rab20 Gene Summary [Rat]
Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport; phagosome acidification; and phagosome-lysosome fusion. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in Golgi apparatus and phagocytic vesicle. Predicted to be active in early endosome; endocytic vesicle; and plasma membrane. Orthologous to human RAB20 (RAB20, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab20 |
| Official Name | RAB20, member RAS oncogene family [Source:RGD Symbol;Acc:1593487] |
| Ensembl ID | ENSRNOG00000023991 |
| Bio databases IDs | |
| Aliases | RAB20, member RAS oncogene family |
| Synonyms | D8Ertd350e, LOC686866, RAB20, member RAS oncogene family |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- biliary atresia
- hypothyroidism
role in cell
- formation
- maturation
- response by
- maturation in
- degradation in
- enlargement in
- fusion in
- acidification
- enlargement
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endosomes
- Golgi Apparatus
- early endosomes
- endocytotic vesicle
- multivesicular bodies
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phagosome-lysosome fusion
- phagosome acidification
- cellular response to interferon-gamma
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- phagocytic vesicle
- endomembrane system
- phagocytic vesicle membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- GTP binding
- GTPase activity