Phkb Gene Summary [Rat]
Predicted to enable calmodulin binding activity. Involved in protein phosphorylation. Part of phosphorylase kinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease IXb. Orthologous to human PHKB (phosphorylase kinase regulatory subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phkb |
| Official Name | phosphorylase kinase regulatory subunit beta [Source:RGD Symbol;Acc:620186] |
| Ensembl ID | ENSRNOG00000024101 |
| Bio databases IDs | |
| Aliases | phosphorylase kinase regulatory subunit beta |
| Synonyms | PHK beta, PHK β, phosphorylase kinase beta, phosphorylase kinase regulatory subunit beta, phosphorylase kinase regulatory subunit β, phosphorylase kinase β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Phkb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein binding
- Phosphorylase b kinase C-terminal domain
Pathways
Biological processes and signaling networks where the Phkb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glycogen storage disease IXB
- glycogen storage disease type IX
- strabismus
- hereditary pancreatitis
- preeclampsia
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Phkb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- glycogen metabolic process
Cellular Component
Where in the cell the gene product is active
- phosphorylase kinase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding