Fgfrl1 Gene Summary [Rat]
Predicted to enable several functions, including fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and heparin binding activity. Predicted to be involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to act upstream of or within several processes, including diaphragm development; heart development; and skeletal system development. Predicted to be located in Golgi apparatus; cell-cell contact zone; and transport vesicle. Predicted to be active in plasma membrane. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgfrl1 |
| Official Name | fibroblast growth factor receptor-like 1 [Source:RGD Symbol;Acc:735156] |
| Ensembl ID | ENSRNOG00000024207 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor receptor-like 1 |
| Synonyms | FGFR-5, FGFR5beta, FGFR5gamma, FHFR, fibroblast growth factor receptor-like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgfrl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- non-tyrosine kinase fibroblast growth factor receptor
- immunoglobulin domain
- Immunoglobulin I-set domain
- identical protein binding
- T-cell surface glycoprotein CD3 delta chain
- fibroblast growth factor receptor
- fibroblast growth factor binding
- L-iduronidase
- Immunoglobulin like
- heparin binding
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Fgfrl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- non-insulin-dependent diabetes mellitus
- hypoplasia
- basioccipital-basisphenoid bone fusion
- fracture of bone
- anemia
- dyspnea
- growth failure
- valvular regurgitation
- pectus excavatum
regulates
- MAPK
- collagen type IV
- FGFR1
- proinsulin
- hemoglobin
- laminin (family)
- YAP/TAZ
role in cell
- proliferation
- apoptosis
- cell death
- number
- cell cycle progression
- adhesion
- fusion
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- intercellular junctions
- transport vesicles
- secretory vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgfrl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- negative regulation of cell proliferation
- fibroblast growth factor receptor signaling pathway
- diaphragm development
- ventricular septum morphogenesis
- heart valve morphogenesis
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- Golgi apparatus
- transport vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- fibroblast growth factor-activated receptor activity
- identical protein binding
- heparin binding
- fibroblast growth factor binding