Cox6b1 Gene Summary [Rat]
Predicted to be involved in substantia nigra development. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to human COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox6b1 |
| Official Name | cytochrome c oxidase subunit 6B1 [Source:RGD Symbol;Acc:1584097] |
| Ensembl ID | ENSRNOG00000024309 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 6B1 |
| Synonyms | 2010000G05Rik, COX6B, COXG, COX VIb-1, cytochrome c oxidase subunit 6B1, cytochrome c oxidase, subunit 6B1, MC4DN7, RGD1565270 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cox6b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_VIb
- enzyme
Pathways
Biological processes and signaling networks where the Cox6b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mitochondrial disorder
- nuclear type 1 mitochondrial complex iv deficiency
- nuclear type 7 mitochondrial complex IV deficiency
- breast cancer
- Huntington disease
- chronic obstructive pulmonary disease
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cox6b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex IV
- mitochondrion
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- cytochrome-c oxidase activity