Cox6b1 Gene Summary [Mouse]

Predicted to be involved in oxidative phosphorylation. Located in mitochondrion. Part of respiratory chain complex IV. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to human COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Cox6b1
Official Name
cytochrome c oxidase, subunit 6B1 [Source:MGI Symbol;Acc:MGI:107460]
Ensembl ID
ENSMUSG00000036751
Bio databases IDs NCBI: 110323 Ensembl: ENSMUSG00000036751
Aliases cytochrome c oxidase, subunit 6B1
Synonyms 2010000G05Rik, COX6B, COXG, COX VIb-1, cytochrome c oxidase subunit 6B1, cytochrome c oxidase, subunit 6B1, MC4DN7, RGD1565270
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox6b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cytochrome-c oxidase
  • Cyt_c_Oxidase_VIb
  • enzyme

Pathways

Biological processes and signaling networks where the Cox6b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • mitochondrial disorder
  • nuclear type 1 mitochondrial complex iv deficiency
  • nuclear type 7 mitochondrial complex IV deficiency
  • breast cancer
  • Huntington disease
  • chronic obstructive pulmonary disease
regulated by
role in cell
  • apoptosis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • interchromatin granule cluster fractions
  • pH resistant lipid raft fraction
  • Mitochondria
  • mitochondrial membrane
  • mitochondrial inner membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox6b1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • mitochondrial electron transport, cytochrome c to oxygen
  • cellular respiration
  • substantia nigra development

Cellular Component

Where in the cell the gene product is active
  • mitochondrial membrane
  • respiratory chain complex IV
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial inner membrane

Molecular Function

What the gene product does at the molecular level
  • cytochrome-c oxidase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.