Mmrn1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway; and positive regulation of platelet aggregation. Predicted to be located in collagen-containing extracellular matrix; extracellular region; and platelet alpha granule. Predicted to be part of multimerin complex. Orthologous to human MMRN1 (multimerin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmrn1 |
| Official Name | multimerin 1 [Source:RGD Symbol;Acc:1587248] |
| Ensembl ID | ENSRNOG00000024986 |
| Bio databases IDs | |
| Aliases | multimerin 1 |
| Synonyms | 4921530G03Rik, ECM, EMILIN4, GPIa*, MMRN, Multimerin, multimerin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmrn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helix-rich Mycoplasma protein
- EMI domain
- EGF domain
- protein binding
- EGF_CA
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- COVID-19
- papillary thyroid cancer
- Parkinson disease
- diabetic nephropathy
- thyroid carcinoma
- epithelial thyroid cancer
- irritable bowel syndrome
- ulcerative colitis
role in cell
- activation
- adhesion
- function
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- perinuclear region
- granules
- alpha granules
- fibrils
- secretory granules
- extracellular matrix
- dense core granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmrn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- cell adhesion mediated by integrin
- cell adhesion
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- platelet alpha granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- extracellular matrix constituent conferring elasticity
- extracellular matrix structural constituent