Cst6 Gene Summary [Rat]
Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within epidermis development. Predicted to be located in cornified envelope. Human ortholog(s) of this gene implicated in ectodermal dysplasia 15. Orthologous to human CST6 (cystatin E/M). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cst6 |
| Official Name | cystatin E/M [Source:RGD Symbol;Acc:628799] |
| Ensembl ID | ENSRNOG00000020455 |
| Bio databases IDs | |
| Aliases | cystatin E/M |
| Synonyms | 1110017E11Rik, CYSTATIN E, cystatin E/M, CYSTATIN M/E, ECTD15, ichq |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cst6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CY
- cysteine protease inhibitor activity
- protein binding
Pathways
Biological processes and signaling networks where the Cst6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- mammary neoplasm
- atopic dermatitis
- hyperplasia
- hypohidrotic/hair type ectodermal dysplasia type 15
- uterine serous papillary cancer
- alopecia
- psoriasis
- keratitis
role in cell
- proliferation
- differentiation
- growth
- migration
- adhesion
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cornified envelope
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cst6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermis development
- anatomical structure morphogenesis
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase inhibitor activity