Hif1an Gene Summary [Rat]
Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Predicted to be involved in negative regulation of Notch signaling pathway; positive regulation of myoblast differentiation; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hif1an |
| Official Name | hypoxia inducible factor 1 subunit alpha inhibitor [Source:RGD Symbol;Acc:1308281] |
| Ensembl ID | ENSRNOG00000014234 |
| Bio databases IDs | |
| Aliases | hypoxia inducible factor 1 subunit alpha inhibitor |
| Synonyms | 2310046M24RIK, A830014H24Rik, FIH, FIH1, hypoxia-inducible factor 1, alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, hypoxia inducible factor 1 subunit α inhibitor, hypoxia-inducible factor 1, α subunit inhibitor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hif1an often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- peptide-aspartate beta-dioxygenase
- NF-kappaB binding
- 2-oxoglutarate:oxygen oxidoreductase
- transcription co-repressor
- transcription factor binding
- protein domain specific binding
- enzyme
- protein binding
- Cupin-like domain
- RmlC-like cupin superfamily
- binding protein
- zinc ion binding
- protein homodimerization
- notch binding
Pathways
Biological processes and signaling networks where the Hif1an gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- hypocapnia
- weight gain
- metastasis
- chronic colitis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- alkalosis
role in cell
- expression in
- proliferation
- migration
- invasion by
- differentiation
- cellular infiltration by
- colony formation by
- production in
- apoptosis
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hif1an gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of vasculogenesis
- positive regulation of myoblast differentiation
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- oxygen sensor activity
- protein homodimerization activity
- peptidyl-asparagine 3-dioxygenase activity
- ferrous iron binding
- Notch binding
- NF-kappaB binding
- carboxylic acid binding
- protein binding
- transcription corepressor activity
- ankyrin repeat binding
- peptidyl-histidine dioxygenase activity