Pla2g3 Gene Summary [Rat]
Predicted to enable calcium-dependent phospholipase A2 activity. Acts upstream of or within negative regulation of gene expression. Predicted to be located in centriole and recycling endosome. Orthologous to human PLA2G3 (phospholipase A2 group III). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g3 |
| Official Name | phospholipase A2, group III [Source:RGD Symbol;Acc:1305323] |
| Ensembl ID | ENSRNOG00000025121 |
| Bio databases IDs | |
| Aliases | phospholipase A2, group III |
| Synonyms | 9130003P18RIK, GIII-SPLA2, phospholipase A2 group III, phospholipase A2, group III, SPLA2III |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent phospholipase A2
- central domain
- enzyme
- phospholipase A2
- phospholipase
- PLA2_like
Pathways
Biological processes and signaling networks where the Pla2g3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- organismal death
- airway hyperresponsiveness
- hypersensitivity reaction type I
- psoriasis
- edema
- passive cutaneous anaphylaxis
- eosinophilia
- ovalbumin-induced asthma
- globozoospermia
regulates
- phosphatidylethanolamine
- phosphatidylserine
- prostaglandin E2
- phosphatidylcholine
- arachidonic acid
- prostaglandin
- IL4
- 1-palmitoyl-lysophosphatidic acid
- phospholipid
- 16:0 lysophosphatidylcholine
role in cell
- apoptosis
- expression in
- proliferation
- formation
- differentiation
- formation in
- activation
- function
- maturation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- centriole
- recycling endosomes
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- high-density lipoprotein particle remodeling
- low-density lipoprotein particle remodeling
- phosphatidylethanolamine metabolic process
- mast cell degranulation
- phospholipid metabolic process
- positive regulation of cytokine production involved in inflammatory response
- macrophage activation
- negative regulation of neuron apoptotic process
- positive regulation of prostaglandin secretion
- production of molecular mediator involved in inflammatory response
- phosphatidylserine metabolic process
- positive regulation of neuron projection development
- positive regulation of mast cell differentiation
- positive regulation of prostaglandin biosynthetic process
- cilium morphogenesis
- negative regulation of beta-amyloid clearance
- phosphatidylinositol metabolic process
- cell maturation
- sperm axoneme assembly
- phosphatidylglycerol metabolic process
- negative regulation of gene expression
- acrosome assembly
- phosphatidylcholine metabolic process
- arachidonic acid secretion
- lipoxygenase pathway
- phosphatidic acid metabolic process
- positive regulation of macrophage derived foam cell differentiation
- regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- centriole
- recycling endosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- calcium-dependent phospholipase A2 activity