Cdca2 Gene Summary [Rat]

This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Details

Type
Protein Coding
Official Symbol
Cdca2
Official Name
cell division cycle associated 2 [Source:RGD Symbol;Acc:1311003]
Ensembl ID
ENSRNOG00000025302
Bio databases IDs NCBI: 305984 Ensembl: ENSRNOG00000025302
Aliases cell division cycle associated 2
Synonyms 2610311M19RIK, cell division cycle associated 2, PPP1R81, Repo-Man
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdca2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein phosphatase 1 binding
  • protein phosphatase regulator
  • PP1 binding domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • liver cancer
  • organismal death
  • inguinal hernia
  • lymphoma
  • lymphomagenesis
  • endometriosis
  • renal clear cell adenocarcinoma
  • renal clear cell cancer
  • hepatocellular carcinoma
regulated by
regulates
role in cell
  • expression in
  • binding in
  • proliferation
  • growth
  • apoptosis
  • G1 phase
  • cohesion
  • cohesion in
  • accumulation in
  • segregation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • cytosol
  • chromosome
  • nucleoplasm
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Cdca2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell division
  • regulation of chromosome segregation
  • regulation of mitosis
  • chromosome segregation
  • positive regulation of protein dephosphorylation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol
  • chromosome
  • nucleoplasm

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.