Cdca2 Gene Summary [Mouse]
Predicted to enable protein phosphatase regulator activity. Acts upstream of or within chromosome segregation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromosome and nucleus. Is expressed in several structures, including brain; liver; lung; metanephros; and retina nuclear layer. Orthologous to human CDCA2 (cell division cycle associated 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdca2 |
| Official Name | cell division cycle associated 2 [Source:MGI Symbol;Acc:MGI:1919787] |
| Ensembl ID | ENSMUSG00000048922 |
| Bio databases IDs | |
| Aliases | cell division cycle associated 2 |
| Synonyms | 2610311M19RIK, cell division cycle associated 2, PPP1R81, Repo-Man |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdca2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 binding
- protein phosphatase regulator
- PP1 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- organismal death
- inguinal hernia
- lymphoma
- lymphomagenesis
- endometriosis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hepatocellular carcinoma
role in cell
- expression in
- binding in
- proliferation
- growth
- apoptosis
- G1 phase
- cohesion
- cohesion in
- accumulation in
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdca2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of chromosome segregation
- regulation of mitosis
- chromosome segregation
- positive regulation of protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- nucleoplasm