Cdkn2b Gene Summary [Rat]
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; negative regulation of cell cycle G1/S phase transition; and negative regulation of glial cell proliferation. Predicted to be active in cytoplasm and nucleus. Used to study endometrial cancer and renal cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to several human genes including CDKN2B (cyclin dependent kinase inhibitor 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn2b |
| Official Name | cyclin-dependent kinase inhibitor 2B [Source:RGD Symbol;Acc:2324] |
| Ensembl ID | ENSRNOG00000006735 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase inhibitor 2B |
| Synonyms | CDK4I, cyclin-dependent kinase inhibitor 2B, INK4B, MTS2, P15, p15INK4b, p15(INK4b) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdkn2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- cyclin-dependent protein kinase inhibitor activity
- transcription regulator
- Ankyrin repeats (many copies)
- protein kinase binding
- Ankyrin repeats (3 copies)
- protein binding
Pathways
Biological processes and signaling networks where the Cdkn2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- lung cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- non-small cell lung cancer
- neoplasia
- liver cancer
- tumorigenesis
- lymphomagenesis
role in cell
- expression in
- transformation
- growth
- proliferation
- number
- differentiation
- quantity
- transcription in
- senescence
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdkn2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of glial cell proliferation
- response to cytokine stimulus
- cellular response to nutrient
- negative regulation of cell proliferation
- cellular senescence
- spleen development
- response to organic cyclic compound
- regulation of cyclin-dependent protein kinase activity
- negative regulation of phosphorylation
- cellular response to cell-matrix adhesion
- cellular response to transforming growth factor beta stimulus
- megakaryocyte differentiation
- positive regulation of epithelial cell differentiation
- liver development
- negative regulation of epithelial cell proliferation
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of G1/S transition of mitotic cell cycle
- regulation of G0 to G1 transition
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- cyclin-dependent protein kinase inhibitor activity